She was Secretary of State with responsibility for foreign policy during the period which saw the rise of ISIS and the transferring of weapons from Libya to them in Iraq. She was also Secretary of State in the period directly preceding the Maidan protests in which the (democratically elected) Yanukovych government was first destabilised and then overthrown. It's fairly widely accepted that Clinton and the Obama administration were laying the groundwork there for a few years previous to that and triggered the coup when Yanukovych backed out of the European Union deal. Her chief spokesperson Victoria Nuland was already a well known aggressive anti-Russian from her time as Dick Chaney's security advisor. Nuland was then made Assistant Secretary of State by Obama on Clinton's retirement and given responsibility carrying through with their Ukrainian 'policy'. Given the timescales involved it's pretty inconceivable she wasn't already working on Ukraine under Clinton. Maybe she wasn't, but as I said arguably both Nuland and Clinton's fingerprints are all over it.